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<channel>
	<title>Natural Health Magazine</title>
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	<description>Health And Wellness </description>
	<lastBuildDate>Tue, 08 Nov 2011 16:22:38 +0000</lastBuildDate>
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		<title>Cholesterol and other Lipids in Your Blood</title>
		<link>http://health-xpert.com/cholesterol-and-other-lipids-in-your-blood</link>
		<comments>http://health-xpert.com/cholesterol-and-other-lipids-in-your-blood#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:38 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
		<category><![CDATA[Education]]></category>
		<category><![CDATA[lipids]]></category>
		<category><![CDATA[metabolism]]></category>
		<category><![CDATA[nutrition]]></category>

		<guid isPermaLink="false">http://health-xpert.com/cholesterol-and-other-lipids-in-your-blood</guid>
		<description><![CDATA[Explore the concept of healthy eating scientifically and shed light on the molecular basis of energy balance. Tracy Fulton of the UCSF Department of Biochemistry and Biophysics explores blood chemistry. Series: &#8220;UCSF Mini Medical School for the Public&#8221; [1/2008] [Health and Medicine] [Show ID: 13727] &#160;Mail this post Technorati Tags: Education, lipids, metabolism, nutrition]]></description>
			<content:encoded><![CDATA[<p>Explore the concept of healthy eating scientifically and shed light on the molecular basis of energy balance. Tracy Fulton of the UCSF Department of Biochemistry and Biophysics explores blood chemistry. Series: &#8220;UCSF Mini Medical School for the Public&#8221; [1/2008] [Health and Medicine] [Show ID: 13727]</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/Education' rel='tag' target='_self'>Education</a>, <a class='technorati-link' href='http://technorati.com/tag/lipids' rel='tag' target='_self'>lipids</a>, <a class='technorati-link' href='http://technorati.com/tag/metabolism' rel='tag' target='_self'>metabolism</a>, <a class='technorati-link' href='http://technorati.com/tag/nutrition' rel='tag' target='_self'>nutrition</a></p>

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		<title>* Cholesterol myth exposed!!  They use it to sell drugs that kill you!</title>
		<link>http://health-xpert.com/cholesterol-myth-exposed-they-use-it-to-sell-drugs-that-kill-you</link>
		<comments>http://health-xpert.com/cholesterol-myth-exposed-they-use-it-to-sell-drugs-that-kill-you#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:37 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
		<category><![CDATA[alternative]]></category>
		<category><![CDATA[bones]]></category>
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		<category><![CDATA[cancer]]></category>
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		<guid isPermaLink="false">http://health-xpert.com/cholesterol-myth-exposed-they-use-it-to-sell-drugs-that-kill-you</guid>
		<description><![CDATA[PLEASE RATE, COMMENT, AND SUBSCRIBE! Download this and any other youtube or google video quickly and easily using the FREE player from http://www.realplayer.com/ DON&#8217;T JUST WATCH THIS, DO SOMETHING ABOUT IT! Show all your friends and family and ESPECIALLY PEOPLE IN POSITIONS OF POWER! TAKE ACTION. Most Americans HAVE NO CLUE that the Federal Reserve [...]]]></description>
			<content:encoded><![CDATA[<p>PLEASE RATE, COMMENT, AND SUBSCRIBE! Download this and any other youtube or google video quickly and easily using the FREE player from http://www.realplayer.com/ DON&#8217;T JUST WATCH THIS, DO SOMETHING ABOUT IT!  Show all your friends and family and ESPECIALLY PEOPLE IN POSITIONS OF POWER! TAKE ACTION.  Most Americans HAVE NO CLUE that the Federal Reserve is a PRIVATE, FOR PROFIT CORPORATION! DON&#8217;T BELIEVE ME, LOOK IT UP FOR YOURSELF AND DO SOMETHING ABOUT IT! JFK, Ron Paul, Woodrow Wilson, Milton Friedman, Ronald Reagan, and many others have spoken against the horrible Federal Reserve system we now have which is unnecessary because our government can print the money without paying interest to the private for profit Federal Reserve. While our government can print money for free, the people who own the private Federal Reserve have made trillions off of creating the US money. They loan money to the US government at interest, when our government could print it without them for free. JFK tried to get rid of the Federal Reserve by printing United States Notes because he realized that if private super rich bankers own the Federal Reserve and they loan money to the government, they essentially own the government. The Federal Reserve is the MAJOR reason why this country has declined financially! The Federal Reserve can be abolished and the government can do the same thing by printing money with United States Notes instead of the Federal Reserve Notes. This will save the country trillions! Watch documentaries like &#8220;Money Masters&#8221; or &#8220;Freedom to Fascism&#8221; for more detailed info on the BIGGEST FINANCIAL SCAM ON THE AMERICAN PEOPLE in History! The Federal Reserve is THE MAJOR REASON why the poor is increasing in numbers and the rich continue to get richer! Stop wasting time with things that don&#8217;t matter like sports or tv. Expose the truth of the corruption going on, and do something about it!</p>
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		</item>
		<item>
		<title>Increase Energy and Lower Cholesterol (2/3)</title>
		<link>http://health-xpert.com/increase-energy-and-lower-cholesterol-23</link>
		<comments>http://health-xpert.com/increase-energy-and-lower-cholesterol-23#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:36 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
		<category><![CDATA[cell]]></category>
		<category><![CDATA[crestor]]></category>
		<category><![CDATA[fuel]]></category>
		<category><![CDATA[gas]]></category>
		<category><![CDATA[hydrogen]]></category>
		<category><![CDATA[Lipitor]]></category>
		<category><![CDATA[lower]]></category>
		<category><![CDATA[mevacor]]></category>
		<category><![CDATA[prices]]></category>
		<category><![CDATA[rising]]></category>
		<category><![CDATA[Statin]]></category>
		<category><![CDATA[Tech]]></category>
		<category><![CDATA[vytorin]]></category>
		<category><![CDATA[zocor]]></category>

		<guid isPermaLink="false">http://health-xpert.com/increase-energy-and-lower-cholesterol-23</guid>
		<description><![CDATA[Get UP and GO (2 of 3) by DoctoR RotcoD. Lifesaving information on how your cells make energy from hydrogen and how Statin drugs block this essential energy-making mechanism. &#160;Mail this post Technorati Tags: cell, crestor, fuel, gas, hydrogen, Lipitor, lower, mevacor, prices, rising, Statin, Tech, vytorin, zocor]]></description>
			<content:encoded><![CDATA[<p>Get UP and GO (2 of 3) by DoctoR RotcoD. Lifesaving information on how your cells make energy from hydrogen and how Statin drugs block this essential energy-making mechanism.</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/cell' rel='tag' target='_self'>cell</a>, <a class='technorati-link' href='http://technorati.com/tag/crestor' rel='tag' target='_self'>crestor</a>, <a class='technorati-link' href='http://technorati.com/tag/fuel' rel='tag' target='_self'>fuel</a>, <a class='technorati-link' href='http://technorati.com/tag/gas' rel='tag' target='_self'>gas</a>, <a class='technorati-link' href='http://technorati.com/tag/hydrogen' rel='tag' target='_self'>hydrogen</a>, <a class='technorati-link' href='http://technorati.com/tag/Lipitor' rel='tag' target='_self'>Lipitor</a>, <a class='technorati-link' href='http://technorati.com/tag/lower' rel='tag' target='_self'>lower</a>, <a class='technorati-link' href='http://technorati.com/tag/mevacor' rel='tag' target='_self'>mevacor</a>, <a class='technorati-link' href='http://technorati.com/tag/prices' rel='tag' target='_self'>prices</a>, <a class='technorati-link' href='http://technorati.com/tag/rising' rel='tag' target='_self'>rising</a>, <a class='technorati-link' href='http://technorati.com/tag/Statin' rel='tag' target='_self'>Statin</a>, <a class='technorati-link' href='http://technorati.com/tag/Tech' rel='tag' target='_self'>Tech</a>, <a class='technorati-link' href='http://technorati.com/tag/vytorin' rel='tag' target='_self'>vytorin</a>, <a class='technorati-link' href='http://technorati.com/tag/zocor' rel='tag' target='_self'>zocor</a></p>

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		<title>Dr. Mercola on Cholesterol Truths (Part 1 of 2)</title>
		<link>http://health-xpert.com/dr-mercola-on-cholesterol-truths-part-1-of-2</link>
		<comments>http://health-xpert.com/dr-mercola-on-cholesterol-truths-part-1-of-2#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:34 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
		<category><![CDATA[cholesterol diet]]></category>
		<category><![CDATA[cholesterol foods]]></category>
		<category><![CDATA[cholesterol levels]]></category>
		<category><![CDATA[cholesterol values]]></category>
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		<category><![CDATA[low cholesterol diet]]></category>
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		<category><![CDATA[reduce cholesterol]]></category>
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		<guid isPermaLink="false">http://health-xpert.com/dr-mercola-on-cholesterol-truths-part-1-of-2</guid>
		<description><![CDATA[http://products.mercola.com/coq10-ubiquinol/ Internationally renowned natural health physician Dr. Joseph Mercola shares the truth about cholesterol. (Part 1 of 2) &#160;Mail this post Technorati Tags: cholesterol, cholesterol diet, cholesterol foods, cholesterol levels, cholesterol values, dr mercola, health, high cholesterol, low cholesterol diet, mercola, reduce cholesterol, Tech]]></description>
			<content:encoded><![CDATA[<p>http://products.mercola.com/coq10-ubiquinol/ Internationally renowned natural health physician Dr. Joseph Mercola shares the truth about cholesterol. (Part 1 of 2)</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/cholesterol' rel='tag' target='_self'>cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/cholesterol+diet' rel='tag' target='_self'>cholesterol diet</a>, <a class='technorati-link' href='http://technorati.com/tag/cholesterol+foods' rel='tag' target='_self'>cholesterol foods</a>, <a class='technorati-link' href='http://technorati.com/tag/cholesterol+levels' rel='tag' target='_self'>cholesterol levels</a>, <a class='technorati-link' href='http://technorati.com/tag/cholesterol+values' rel='tag' target='_self'>cholesterol values</a>, <a class='technorati-link' href='http://technorati.com/tag/dr+mercola' rel='tag' target='_self'>dr mercola</a>, <a class='technorati-link' href='http://technorati.com/tag/health' rel='tag' target='_self'>health</a>, <a class='technorati-link' href='http://technorati.com/tag/high+cholesterol' rel='tag' target='_self'>high cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/low+cholesterol+diet' rel='tag' target='_self'>low cholesterol diet</a>, <a class='technorati-link' href='http://technorati.com/tag/mercola' rel='tag' target='_self'>mercola</a>, <a class='technorati-link' href='http://technorati.com/tag/reduce+cholesterol' rel='tag' target='_self'>reduce cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/Tech' rel='tag' target='_self'>Tech</a></p>

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		<title>Cholesterol Absorption &#8211; 3D Animation Mechanism of Action</title>
		<link>http://health-xpert.com/cholesterol-absorption-3d-animation-mechanism-of-action</link>
		<comments>http://health-xpert.com/cholesterol-absorption-3d-animation-mechanism-of-action#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:32 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
		<category><![CDATA[Absorbtion]]></category>
		<category><![CDATA[film]]></category>

		<guid isPermaLink="false">http://health-xpert.com/cholesterol-absorption-3d-animation-mechanism-of-action</guid>
		<description><![CDATA[Producer, 3D Animation Director, Editor &#160;Mail this post Technorati Tags: Absorbtion, cholesterol, film]]></description>
			<content:encoded><![CDATA[<p>Producer, 3D Animation Director, Editor</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/Absorbtion' rel='tag' target='_self'>Absorbtion</a>, <a class='technorati-link' href='http://technorati.com/tag/cholesterol' rel='tag' target='_self'>cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/film' rel='tag' target='_self'>film</a></p>

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		<title>Part 1: Cholesterol (BMA Leeds)</title>
		<link>http://health-xpert.com/part-1-cholesterol-bma-leeds</link>
		<comments>http://health-xpert.com/part-1-cholesterol-bma-leeds#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:31 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
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		<category><![CDATA[Statin]]></category>
		<category><![CDATA[Tech]]></category>
		<category><![CDATA[Thincs]]></category>

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		<description><![CDATA[Dr Malcolm Kendrick speaks to Leeds BMA Meeting about why Cholesterol does not cause heart disease. see www.thincs.org &#160;Mail this post Technorati Tags: cholesterol, CVD, diet, doctor, fat, Heart, Kendrick, Malcolm, Side-effects, Statin, Tech, Thincs]]></description>
			<content:encoded><![CDATA[<p>Dr Malcolm Kendrick speaks to Leeds BMA Meeting about why Cholesterol does not cause heart disease. see www.thincs.org</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/cholesterol' rel='tag' target='_self'>cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/CVD' rel='tag' target='_self'>CVD</a>, <a class='technorati-link' href='http://technorati.com/tag/diet' rel='tag' target='_self'>diet</a>, <a class='technorati-link' href='http://technorati.com/tag/doctor' rel='tag' target='_self'>doctor</a>, <a class='technorati-link' href='http://technorati.com/tag/fat' rel='tag' target='_self'>fat</a>, <a class='technorati-link' href='http://technorati.com/tag/Heart' rel='tag' target='_self'>Heart</a>, <a class='technorati-link' href='http://technorati.com/tag/Kendrick' rel='tag' target='_self'>Kendrick</a>, <a class='technorati-link' href='http://technorati.com/tag/Malcolm' rel='tag' target='_self'>Malcolm</a>, <a class='technorati-link' href='http://technorati.com/tag/Side-effects' rel='tag' target='_self'>Side-effects</a>, <a class='technorati-link' href='http://technorati.com/tag/Statin' rel='tag' target='_self'>Statin</a>, <a class='technorati-link' href='http://technorati.com/tag/Tech' rel='tag' target='_self'>Tech</a>, <a class='technorati-link' href='http://technorati.com/tag/Thincs' rel='tag' target='_self'>Thincs</a></p>

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		<title>Statin Drugs: What You Need to Know!</title>
		<link>http://health-xpert.com/statin-drugs-what-you-need-to-know</link>
		<comments>http://health-xpert.com/statin-drugs-what-you-need-to-know#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:30 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
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		<description><![CDATA[http://articles.mercola.com/sites/articles/archive/2010/07/20/the-truth-about-statin-drugs-revealed.aspx Leading natural health expert Dr. Joseph Mercola talks about the dangers and side effects of taking statin drugs and how to optimize your cholesterol levels naturally. &#160;Mail this post Technorati Tags: chlolesterol, co-enzyme q10, coq10, dr mercola, health, heart disease, high cholesterol, lower cholesterol, mercola, News, nutritional typing, statin drugs, statins, ubiquinol]]></description>
			<content:encoded><![CDATA[<p>http://articles.mercola.com/sites/articles/archive/2010/07/20/the-truth-about-statin-drugs-revealed.aspx Leading natural health expert Dr. Joseph Mercola talks about the dangers and side effects of taking statin drugs and how to optimize your cholesterol levels naturally.</p>
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<p class='technorati-tags'>Technorati Tags: <a class='technorati-link' href='http://technorati.com/tag/chlolesterol' rel='tag' target='_self'>chlolesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/co-enzyme+q10' rel='tag' target='_self'>co-enzyme q10</a>, <a class='technorati-link' href='http://technorati.com/tag/coq10' rel='tag' target='_self'>coq10</a>, <a class='technorati-link' href='http://technorati.com/tag/dr+mercola' rel='tag' target='_self'>dr mercola</a>, <a class='technorati-link' href='http://technorati.com/tag/health' rel='tag' target='_self'>health</a>, <a class='technorati-link' href='http://technorati.com/tag/heart+disease' rel='tag' target='_self'>heart disease</a>, <a class='technorati-link' href='http://technorati.com/tag/high+cholesterol' rel='tag' target='_self'>high cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/lower+cholesterol' rel='tag' target='_self'>lower cholesterol</a>, <a class='technorati-link' href='http://technorati.com/tag/mercola' rel='tag' target='_self'>mercola</a>, <a class='technorati-link' href='http://technorati.com/tag/News' rel='tag' target='_self'>News</a>, <a class='technorati-link' href='http://technorati.com/tag/nutritional+typing' rel='tag' target='_self'>nutritional typing</a>, <a class='technorati-link' href='http://technorati.com/tag/statin+drugs' rel='tag' target='_self'>statin drugs</a>, <a class='technorati-link' href='http://technorati.com/tag/statins' rel='tag' target='_self'>statins</a>, <a class='technorati-link' href='http://technorati.com/tag/ubiquinol' rel='tag' target='_self'>ubiquinol</a></p>

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		<title>Truth About High Cholesterol &#8211; Austin Wellness Institute</title>
		<link>http://health-xpert.com/truth-about-high-cholesterol-austin-wellness-institute</link>
		<comments>http://health-xpert.com/truth-about-high-cholesterol-austin-wellness-institute#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:28 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
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		<description><![CDATA[Be My Friend &#8211; http://www.myspace.com/psychtruthTruth About High Cholesterol &#8211; Austin Wellness InstituteShould you take medications for high cholesterol? Is high cholesterol even a bad thing?Common Statin drugs include Lipitor, Crestor, Zocor, Lipex, Torvast, Lipobay, Lescol, Mevacor, Altocor, Livalo, Pitava.Visit Dr. Bellonzi&#8217;s website athttp://www.bewellrx.comhttp://www.austinwellnessinstitute.comThis video was produced by Psychetruthhttp://www.myspace.com/psychtruthhttp://www.youtube.com/psychetruth Copyright 2008 Austin Wellness Institute. All Rights [...]]]></description>
			<content:encoded><![CDATA[<p>Be My Friend &#8211; http://www.myspace.com/psychtruthTruth About High Cholesterol &#8211; Austin Wellness InstituteShould you take medications for high cholesterol? Is high cholesterol even a bad thing?Common Statin drugs include Lipitor, Crestor, Zocor, Lipex, Torvast, Lipobay, Lescol, Mevacor, Altocor, Livalo, Pitava.Visit Dr. Bellonzi&#8217;s website athttp://www.bewellrx.comhttp://www.austinwellnessinstitute.comThis video was produced by Psychetruthhttp://www.myspace.com/psychtruthhttp://www.youtube.com/psychetruth Copyright 2008 Austin Wellness Institute. All Rights Reserved.</p>
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		<title>Truth About High Cholesterol &amp; Statins Drugs like Lipitor</title>
		<link>http://health-xpert.com/truth-about-high-cholesterol-statins-drugs-like-lipitor</link>
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		<pubDate>Tue, 08 Nov 2011 16:22:26 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
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		<description><![CDATA[MySpace Friend Me!http://www.myspace.com/psychtruthTruth About High Cholesterol &#38; Statins Drugs like LipitorWhats the truth about high and cholesterol cholesterol lowing drugs like Lipitor, Lescol, Altocor, Pravachol, Crestor and Zocor? Dr. Vincent Bellonzi is a chiropractor and is certified in Clinical Nutrition. He has been in practice for over 12 years. He received his Doctorate from Los [...]]]></description>
			<content:encoded><![CDATA[<p>MySpace Friend Me!http://www.myspace.com/psychtruthTruth About High Cholesterol &amp; Statins Drugs like LipitorWhats the truth about high and cholesterol cholesterol lowing drugs like Lipitor, Lescol, Altocor, Pravachol, Crestor and Zocor? Dr. Vincent Bellonzi is a chiropractor and is certified in Clinical Nutrition. He has been in practice for over 12 years. He received his Doctorate from Los Angeles College of Chiropractic in 1991.Since 1998, Dr. Bellonzi has practiced in the Austin area. He works with athletes at every level to provide sports conditioning and rehabilitation.Visit Dr. Bellonzi&#8217;s website athttp://www.austinwellnessclinic.com/This video was produced by Psychetruthhttp://www.myspace.com/psychtruthhttp://www.youtube.com/psychetruthhttp://psychetruth.blogspot.com/PsycheTruth is empowered by TubeMogulhttp://www.tubemogul.com Copyright 2008 Austin Wellness Institute. All Rights Reserved.  Distributed by Tubemogul.</p>
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		<title>Bite-Sized Biochemistry #35 &#8211; Fat, Lipid &amp; Cholesterol Movement in the Body</title>
		<link>http://health-xpert.com/bite-sized-biochemistry-35-fat-lipid-cholesterol-movement-in-the-body</link>
		<comments>http://health-xpert.com/bite-sized-biochemistry-35-fat-lipid-cholesterol-movement-in-the-body#comments</comments>
		<pubDate>Tue, 08 Nov 2011 16:22:24 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[cholesterol]]></category>
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		<description><![CDATA[(01/07/11) Lecture by Kevin Ahern of Oregon State University discussing Biochemistry Basics in BB 451. See the full course at http://oregonstate.edu/instruction/bb451/index.htmlThis course can be taken for credit (wherever you live) via OSU&#8217;s ecampus. For details, see http://ecampus.oregonstate.edu/soc/ecatalog/ecourselist.htm?termcode=all&#38;&#8230;Download Metabolic Melodies at http://www.davincipress.com/metabmelodies.htmlRelated courses includeBB 350 &#8211; http://oregonstate.edu/instruction/bb350/BB 450 &#8211; http://oregonstate.edu/instruction/bb451/BB 100 &#8211; http://oregonstate.edu/instruction/bb100/1. An enzyme known [...]]]></description>
			<content:encoded><![CDATA[<p>(01/07/11) Lecture by Kevin Ahern of Oregon State University discussing Biochemistry Basics in BB 451. See the full course at http://oregonstate.edu/instruction/bb451/index.htmlThis course can be taken for credit (wherever you live) via OSU&#8217;s ecampus. For details, see http://ecampus.oregonstate.edu/soc/ecatalog/ecourselist.htm?termcode=all&amp;&#8230;Download Metabolic Melodies at http://www.davincipress.com/metabmelodies.htmlRelated courses includeBB 350 &#8211; http://oregonstate.edu/instruction/bb350/BB 450 &#8211; http://oregonstate.edu/instruction/bb451/BB 100 &#8211; http://oregonstate.edu/instruction/bb100/1. An enzyme known as thiolase is responsible for putting together two acetyl-CoA molecules to create the acetoacetyl-CoA, which is used to make HMG-CoA.2. Conversion of lanosterol to cholesterol is a complex, energy intensive process that requires 19 steps and a lot of energy.3. SREBP (Steroid response element binding protein) is a protein that plays a role in controlling whether or not HMG-CoA reductase is made. When cholesterol is abundant, SREBP is found in the membrane of the endoplasmic reticulum linked to another protein called SCAP through the regulatory (REG) region of SREBP.4. When cholesterol levels in the cell fall, the SCAP/SREBP complex moves to the Golgi Complex and SCAP binds to a serine protease. The serine protease cleaves SREBP to release the REG region from the region that will ultimately bind to DNA. Highlights Fat/Lipid/Cholesterol Transport1. Cholesterol in the body is either there as a result of 1) synthesis; 2) diet; or 3) storage/recycling.2. In the digestive system, bile acids and mechanical agitation of the stomach help emulsify fats.3. In the intestines, hydrolysis of fatty acids from fats by lipases (pancreatic lipase), yield soapy like substances that help emulsify lipids for transport across the intestinal wall.4. After movement across the intestine, lipids are packaged in chylomicrons. They move through the lymph system into the capillaries where they get stuck.5. Action of lipoprotein lipase in the capillaries removes some of the fat from the chylomicrons and they shrink in size and exit the capillaries and move to the liver.6. The liver is involved in sensing the body&#8217;s need for lipids via LDL receptors. If it senses lipids are needed, VLDLs are packaged by the liver and released these get degraded by lipases and other enzymes to IDLs and LDLs. If the liver LDL receptor cannot detect LDLs in the blood, it continues to release more lipids in lipoprotein complexes.7. Defects in liver LDL receptors can cause high blood cholesterol. Other factors to consider include dietary cholesterol, cholesterol synthesis rate, and efficiency of recycling cholesterol. Statins are drugs that inhibit HMG-CoA Reductase and reduce cholesterol by inhibiting its synthesis. Drugs, such as Ezetemibe, are available to block reabsorption of cholesterol in recycling.8. LDLs are are associated with formation of atherosclerotic plaques. These may form as a result of free radical (reactive oxygen) species which oxidize unsaturated fatty acids in LDLs. The immune system may attack these and form the basis of an atherosclerotic plaque.9. HDLs, by contrast, are associated with reducing levels of cholesterol. HDLs are reduced in smokers, but are increased in response to exercise.10. If a person has high cholesterol, the first approach is to see if levels can be brought down by dietary changes. If they cannot, then drugs are used to stop 1) endogenous synthesis and/or 2) recycling.11. Endogenous synthesis drugs target HMG-CoA Reductase. These drugs are called Statins (for example, lovastatin) and they stop the pathway that leads to cholesterol.12. Factors increasing LDLs include smoking, obesity, and saturated fats in the diet.13. Factors increasing HDLs include exercise and factors decreasing them include obesity and smoking.</p>
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